Interneurons in the developing human neocortex
نویسندگان
چکیده
منابع مشابه
Layer specification of transplanted interneurons in developing mouse neocortex.
The six-layered neocortex is composed of excitatory projection neurons and inhibitory interneurons. Recent studies have established separate embryological origins for these two cellular populations. However, it remains uncertain how interneurons arising from the subcortical ganglionic eminences are able to participate in the orderly stratification of the cortical layers. A related question conc...
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NG2 cells, oligodendrocyte progenitors, receive a major synaptic input from interneurons in the developing neocortex. It is presumed that these precursors integrate cortical networks where they act as sensors of neuronal activity. We show that NG2 cells of the developing somatosensory cortex form a transient and structured synaptic network with interneurons that follows its own rules of connect...
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The interactions between migrating interneurons and their environment that lead to stereotypic migration pathways remain largely undefined. We have used time-lapse imaging to record the migratory responses of labeled interneurons to different regions of the migratory pathway in organotypic slice cultures. We tested the hypothesis that the length of the migratory pathway is not equally permissiv...
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Cortical networks are composed of glutamatergic excitatory projection neurons and local GABAergic inhibitory interneurons that gate signal flow and sculpt network dynamics. Although they represent a minority of the total neocortical neuronal population, GABAergic interneurons are highly heterogeneous, forming functional classes based on their morphological, electrophysiological, and molecular f...
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Commentary Does impaired inhibition cause epilepsy? Does epilepsy alter inhibitory circuits? These longstanding questions have few clear answers. A recent study by Jin et al. provides a fascinating view of the inputs and outputs of an inhibitory circuit in chronically epileptic neocortex and highlights the complexity of circuit reorganization following injury. The choice of experimental model i...
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ژورنال
عنوان ژورنال: Developmental Neurobiology
سال: 2010
ISSN: 1932-8451
DOI: 10.1002/dneu.20812